Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
disease ct 4 0.035 0.697 0.203 0.285
disease el 4 0.301 0.757 0.571 0.166
disease ka 4 0.004 0.656 0.173 0.279
disease rf 4 0.034 0.696 0.203 0.285
genetic_interaction el 9 0.0 0.991 0.605 0.358
genetic_interaction ka 9 0.0 0.226 0.159 0.087
genetic_interaction rf 9 0.0 0.989 0.607 0.355
phenotype ka 4 0.005 0.648 0.298 0.293

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 11 0.001 0.963 0.327 0.397
integration_mean_by_presence el 11 0.0 0.797 0.232 0.288
integration_mean_by_presence ka 11 0.0 0.447 0.179 0.17
integration_mean_by_presence rf 11 0.0 0.809 0.243 0.278
mean ct 11 0.0 0.967 0.329 0.397
mean el 11 0.0 0.368 0.092 0.124
mean ka 11 0.0 0.279 0.093 0.101
mean rf 11 0.0 0.352 0.11 0.117

CDF plots of non integrated kernels

CDF plots of integrated kernels